Plasma Conditioned Liquids to enhance the effect of chemotherapy against bone metastasis

Former member of the ERC APACHE Project Dr. Miguel Mateu-Sanz, together with other members of the team, have worked in this investigation, whose main objective is to increase the efficiency of doxorubicin drug against metastatic bone cancer.

High-dose chemotherapy constitutes a main strategy against bone metastases, which involves severe side effects. This work aimed to benefit from the high sensibility of prostate cancer cells against reactive oxygen and nitrogen species (RONS) produced in aqueous solutions to reduce the dose of doxorubicin in the treatment of this bone metastasis and diminish its negative effects in bone tissue.

We invite you to check this novel research in redox biology employing cold plasmas for bone cancer treatment: Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cancer. Miguel Mateu-Sanz, María-Pau Ginebra, Juan Tornín and Cristina Canal. Free Rad. Biol. and Med., 2022, doi: http://doi.org/10.1016/j.freeradbiomed.2022.07.007