Divulgation

F. Tampieri, M.P. Ginebra, C. Canal. Quantification of Plasma-Produced Hydroxyl Radicals in Solution and their Dependence on the pH. Anal. Chem., 2021.

Video: pubs.acs.org/doi/suppl/10.1021/acs.analchem.0c04906

OPEN ACCESS PUBLICATION

Abstract
HO radicals are the most important reactive species generated during water treatment by non-thermal plasma devices. In this letter, we report the first quantification of the steady-state concentration and lifetime of plasma-produced hydroxyl radicals in water solutions at pH 3 and 7, and we discuss the differences based on their reactivity with other plasma-generated species. Finally, we show to what extent the use of chemical probes to quantify short-lived reactive species has an influence on the results and that it should be taken into account.

Spanish JCR Journal

I. Hamouda, J. Guillem-Marti, M.P. Ginebra, C. Canal. Liquids treated by Atmospheric Pressure Plasma Jet for bone cancer therapy (Award SIBB 2017 Conference). Biomecánica, Vol.25, 2017, pp 7-15.

OA:https://upcommons.upc.edu/handle/2117/119824

OPEN ACCESS PUBLICATION

Abstract
Current bone cancer treatments include and may combine surgery, chemotherapy, radiation therapy or cryosurgery among others. However, these treatments are not completely effective and unspecific where patients relapse. In recent years, researchers have found a novel approach by means of cold atmospheric plasma that can selectively treat cancer cells without damaging the surrounding tissues but its effects on bone cancer are unknown. Cold plasmas generate reactive oxygen and nitrogen species in air, which seem to be related to their effects on cells. As biological tissues and cells are covered with biological fluids during plasma treatment, studies point out an implication of the liquid media in the effects of plasmas. Within this context, in this research project the effect of an atmospheric pressure plasma jet will be investigated in two different liquid media by implementing appropriate measurement protocols for three different reactive species: [H2O2]; [HO•] and [NO2-]. To ascertainits biological effects this atmospheric pressure plasma jet treated liquids will be put in contact with bone cancer cells (SaOs-2) and also with healthy bone cells (Hobs). Preliminary results show that the atmospheric pressure plasma jet treated liquids contain different amounts of the studied reactive species depending on the treatment conditions and the medium employed, and can selectively kill bone cancer cells while conserving the viability of healthy bone cells.